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The serine/threonine kinase pim-2 was the most down-regulated of 9500 genes and ESTs between 0 and 12 h of IL-3 withdrawal ( p < 0.0005). This change in pim-2 expression was confirmed via Northern blot. The pim-2 transcript dropped within 6 h of cytokine withdrawal and was undetectable at 12 h ( Fig. 1A ).


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Pim-2 kinase is overexpressed in multiple myeloma (MM) cells to enhance their growth and survival, and regarded as a novel. 20 and activin A.21,22 Although Pim-2 appears to be an important.


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PIM-2 kinase is expressed in hematopoietic cells and functions by phosphorylating various target substrates and thus subsequently affects cell survival, cell proliferation, transcriptional activation, and protein translation.. 21, 28, and 35 are shown (n = 14 mice per group).


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Pim-2 kinase is overexpressed in multiple myeloma (MM) cells to enhance their growth and survival, and regarded as a novel therapeutic target in MM. However, the impact of Pim-2 inhibition on bone.


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transcriptional induction of Pim-2 initiates a novel NF-kappaB activation pathway that regulates cell survival. This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. [provided by RefSeq, Nov 2009]


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Pondok Indah Mall (Indonesian: Mal Pondok Indah), abbreviated as PIM, is a large shopping mall complex located in the Pondok Indah suburb of South Jakarta, Indonesia.In January 2017, it was recognised by Forbes as one of the top five shopping malls in Jakarta. The Pondok Indah Mall complex comprises three large main buildings, the older 3-storey PIM1 and the 5-storey PIM2, and the newest.


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Pim-2 kinase exerts its oncogenic effects by phosphorylating target proteins involved in cell cycle and proliferation [19,20,21]. Pim-2 kinase phosphorylates BAD at serine 112 and reverses BAD-induced cell death . Pim-2 kinase is involved in the transduction of a variety of cellular signaling pathways, thereby promoting tumorigenesis.


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Results showed that, while PIM-2 negatively regulates T cells, PIM-1 and PIM-3 positively regulate T cell activation. "Imagine that the therapy is a car," explains Yu. "If you want it to go faster.